21-25 August 2012
Portorož, Slovenia
UTC timezone
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Using Weighted Voronoi Diagrams to describe Proteomic Maps

Presented by Rok OREL
Type: Poster

Content

In this work we investigate the problem of numerical characterization of two dimensional proteomics maps based on construction of Voronoi regions. To enable for the taking into account of the concentrations of proteins on the proteomic map, we have used the process which gives greater weights to spots representing proteins with greater abundance. As we have shown, the shapes of the resulting Voronoi regions are sensitive to relative abundances of the proteins spots. In this work the spot abundances are naturally incorporated in the numerical analysis, as a partitioning of the plane. We investigated a series of proteomic maps, where experimental animals being administered the same peroxisome proliferator, albeit in different concentrations, we explore the properties of the dual graph of the partitioning of the plane and compare the results of this novel method with approaches encountered in the literature. In doing this we have observed a J-shaped dose-response curve, typical of hormesis, similar to the results published previously but using a method that is independent. Keywords Proteomics maps • Voronoi regions • LY171833 Peroxisome proliferator • Weighted Voronoi regions

Place

Location: Portorož, Slovenia
Address: University of Primorska, Faculty of Tourism Studies, Obala 11a, SI-6320 Portorož - Portorose, Slovenia
Room: VP1

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